The Binding of Isaac

The Binding of Isaac is a roguelike game released on Microsoft Windows and Mac OS X on September 28, 2011. Based on the Biblical tale of "the binding of Isaac", the game follows a young boy named Isaac whose mother attempts to kill him after hearing a voice she believes to be God. Escaping into his monster-ridden basement, he must fight to survive.

Plot
A boy named Isaac and his mother live alone in their house on a hill. Isaac keeps to himself, playing with his toys and drawing pictures while his mother watches Christian broadcasts on the television. They live happily together, until one day Isaac's mother hears a voice she believes to be God. The voice orders her to take away all that could corrupt Isaac, and acting on its orders, she takes away his toys, drawings, and even his clothes. Again on the voice's orders, she locks Isaac in his room.

The voice orders her a final time to kill Isaac as a sign of her devotion. Seeing his mother coming through a crack in his door, Isaac escapes through a trapdoor into his basement.

Development
The game was inspired by McMillen's experience growing up in a born-again Christian household.

Trivia

 * The BibleThump emote on Twitch is derived from the game's main character.