| Game | Year | Developer | Publisher |
|---|---|---|---|
| 20 em 1 | 1995 | Tec Toy Indústria de Brinquedos S.A. | |
| 20 Giant Games | 1997 | Beau Jolly | |
| 20 Mega Games | 1997 | Empire Interactive Europe Ltd. | |
| 20 Pferdespiele | 2006 | TOPOS Verlag GmbH | |
| 20 Squares | 1995 | ||
| 20,000 Leagues Under the Sea | 1988 | Coktel Vision | |
| 20,000 Leagues Under the Sea: Captain Nemo | 2009 | Game Factory Interactive Ltd. | |
| 2001 Alien Combat | 2000 | Cursoft@ | |
| 2002 FIFA World Cup | 2002 | Electronic Arts, Inc. | |
| 2004 Long Jump | 2004 | Mobile2win Ltd. | |
| 2004 Real Soccer | 2004 | Gameloft S.A. | |
| 2004: Space Becherovka | 2004 | Dast | |
| 2005 MiniGame MultiCart | 2005 | AtariAge | |
| 2005 Real Soccer | 2005 | Gameloft S.A. | |
| 2005 Traffic | 2005 | Just Flight Ltd. | |
| 2006 FIFA World Cup | 2006 | Electronic Arts, Inc. | |
| 2006 Real Soccer | 2006 | Gameloft S.A. | |
| 2010 FIFA World Cup South Africa | 2010 | Electronic Arts, Inc. | |
| 2010: The Graphic Action Game | 1984 | Coleco Industries, Inc. | |
| 2014 FIFA World Cup Brazil | 2014 | Electronic Arts, Inc. | |
| 2020 Special Ops | 2005 | Concrete Software, Inc. | |
| 2025: Battle for Fatherland | 2010 | Akella | |
| 2060 Cyber Racer | 2009 | ||
| 2088 | 1988 | Zeppelin Games Limited | |
| 21 Gewinnt | 1992 | ||
| 21-en | 1991 | HVB | |
| 21: Blackjack | 2010 | Digital Leisure Inc. | |
| 2112 - A Field Trip | 2001 | ||
| 2176 Supernova Storm | 2009 | ||
| 221 B Baker St. | 1986 | Datasoft, Inc. | |
| 24 Tested Ready-To-Run Game Programs in BASIC | 1978 | Tab Books | |
| 24: The Game | 2006 | 2K Games, Inc. | |
| 2400 A.D. | 1987 | ORIGIN Systems, Inc. | |
| 25 to Life | 2006 | Eidos Interactive Ltd. | |
| 25,000 Sudoku Puzzles | 2005 | Focus Multimedia Ltd. | |
| 2 for 1: The Messenger & Traitors Gate | 2004 | The Adventure Company | |
| 2 for 1: The Mystery of the Nautilus / The New Adventures of the Time Machine | 2004 | The Adventure Company | |
| 2 for 1: Riddle of the Sphinx & Riddle of the Sphinx II | 2004 | The Adventure Company | |
| 2 For You Game Pack: Super Aneurysm! / Pop Pop Pop! | 2006 | ValuSoft, Inc. | |
| 2 Games In 1: Cartoon Network Block Party & Cartoon Network Speedway | 2005 | Majesco Sales, Inc. | |
| 2 Games in 1: Columns Crown + ChuChu Rocket! | 2005 | THQ Inc. | |
| 2 Games in 1: Disney Princess + Disney's The Lion King 1½ | 2004 | THQ Inc. | |
| 2 Games in 1: GT 3 Advance: Pro Concept Racing + Moto GP: Ultimate Racing Technology | 2004 | THQ Inc. | |
| 2 Games in 1: Power Rangers: Time Force / Power Rangers: Ninja Storm | 2005 | THQ Inc. | |
| 2 Games in 1: SpongeBob SquarePants - Battle for Bikini Bottom + SpongeBob SquarePants - Supersponge | 2004 | THQ Inc. | |
| 2 Good 2 Be True: Volume 1 | 1997 | Sierra On-Line, Inc. | |
| 2 Hot 2 Handle | 1991 | Ocean Software Ltd. | |
| 2 in 1 Game Pack: Spider-Man: Mysterio's Menace / X2: Wolverine's Revenge | 2005 | Activision Publishing, Inc. | |
| 2 in 1: Cross High & Block Buster | 1992 | Watara | |
| 2 in 1: DreamWorks' Shark Tale + Shrek 2 | 2005 | Activision Publishing, Inc. | |
| 2 in 1: Hash Block & Eagle Plan | 1991 | Watara | |
| 2 in 1: V-Rally 3 + Stuntman | 2005 | Atari Europe S.A.S.U. | |
| 2 in1 Pack - Jack Nicklaus 5 + Daley Thompson's Decathlon | 1999 | Swing! Entertainment Software GmbH | |
| 2 Pak Special: Alien Force & Hoppy | 1992 | Home Entertainment Suppliers Pty. Ltd | |
| 2 Pak Special: Cavern Blaster & City War | 1992 | Home Entertainment Suppliers Pty. Ltd. | |
| 2 Pak Special: Space Voyage & Fire Alert | 1992 | Home Entertainment Suppliers Pty. Ltd. | |
| 2 Pics 1 Answer | 2014 | Dingleberry Studios | |
| 2 Player Soccer Squad | 1991 | D&H Games | |
| 2 Shot Diary | 1994 | Mink Co. Ltd. | |
| 2 Shot Diary 2: Memory 1/4 | 1995 | Mink Co. Ltd. | |
| 2 Shot Diary 2: Memory 2/4 | 1996 | Mink Co. Ltd. | |
| 2 Shot Diary 2: Memory 3/4 | 1996 | Mink Co. Ltd. | |
| 2 Shot Diary 2: Memory 4/4 | 1996 | Mink Co. Ltd. | |
| 2 Tasty | 2010 | Maximize Games | |
| 2Fast 2Furious | 2002 | Xister | |
| 2in1 Pack: Battle Arena Toshinden - Fatal Fury 3 | 1999 | Swing! Entertainment Software GmbH | |
| 2in1 Pack: Bundesliga Manager Gold - Eishockey Manager | 1999 | Swing! Entertainment Media AG | |
| 2in1 Pack: Dragon's Lair - Space Ace | 1998 | Swing! Entertainment Software GmbH | |
| 2in1 Pack: Dream Team 98 - ranSoccer | 1998 | Swing! Entertainment Software GmbH | |
| 2in1 Pack: Hanse: Die Expedition - Der Patrizier | 1998 | Swing! Entertainment Software GmbH | |
| 2in1 Pack: Jack Nicklaus 4 - Tennis Manager | 1999 | Swing! Entertainment Software GmbH | |
| 2in1 Pack: St. Thomas - Elisabeth I. | 1999 | Swing! Entertainment Software GmbH | |
| 2in1: Zirkus Tycoon + Airline Tycoon Deluxe | 2006 | Halycon Media GmbH & Co. KG | |
| 2K-Fighter | 1992 | 64'er | |
| 2K Essentials Collection: BioShock / Borderlands / XCOM: Enemy Unknown | 2013 | 2K Games, Inc. | |
| 2K Huge Game Pack | 2009 | 2K Games, Inc. | |
| 2K Power Pack: The Darkness II / BioShock 2 / Mafia II | 2013 | 2K Games, Inc. | |
| 2onOne: L.A. Swat + Panther | 1988 | Mastertronic, Inc. | |
| 2x2 | 2012 | AnyTech, Inc. | |
| 2x2 | 1995 | Ajt Soft | |
| 2Xtreme | 1996 | Sony Computer Entertainment America, Inc. |
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