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The Dominion is an imperialist xenophobic political organisation located in the Gamma Quadrant in the Star Trek universe. They have been referenced in relatively few video games.
The Dominion is ruled by a collective of non-humanoids called Changelings, referred to as the "Founders". Their will is exercised through the Vorta, a genetically-enhanced humanoid species. The Vorta in turn exercise military power through the Jem'Hadar, a species of genetically-enhanced super-soldiers bred to be addicted to a drug called Ketracel-White, the dispensation of which allows the Vorta to exercise control over them by ensuring that only soldiers who obey get to continue to live.