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Dr. Mario 64 is a 2001 puzzle video game by Nintendo, for the Nintendo 64 in North America. The game is based on the original NES game, Dr. Mario. Mario stars as his alter-ego, Dr. Mario on where he stars as a doctor in this game.
There are different modes to add a minimal amount of spice to what is otherwise, exactly the same as the original NES game. Classic, score attack, marathon, different objectives for each mode. Flash mode is a new one that requires Dr. Mario to get rid of a certain amount of flashing viruses. Most gamers probably can find the[replay value in the multiplayer mode, where friends/enemies can puzzle it out in a four person free for all, or in teams of two. To frustrate enemies, players with garbage falling on their side. Dr. Mario has to get rid of virsues in multiple combos.