Ratchet & Clank: Up Your Arsenal is the third game in the Ratchet & Clank series on the PlayStation 2. It is more action-based then the previous two and there is more war. Ratchet & Clank need to find and destroy Doctor Nefarious who has gone crazy.

There are some mini-levels where Captain Qwark is a playable character. These segments tell stories of his past adventures.

The game starts with Ratchet and Clank playing some strange board game, and watching Secret Agent Clank, a TV show starring Clank. A jealous Ratchet changes the channel and finds out that his home planet, Veldin, is under attack. He flies there, and the adventure begins.

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